- Title
- Switching strategies to mitigate HIV mutation
- Creator
- Hernandez-Vargas, Esteban Abelardo; Colaneri, Patrizio; Middleton, Richard H.
- Relation
- IEEE Transactions on Control Systems Technology Vol. 22, Issue 4, p. 1623-1628
- Publisher Link
- http://dx.doi.org/10.1109/TCST.2013.2280920
- Publisher
- Institute of Electrical and Electronics Engineers (IEEE)
- Resource Type
- journal article
- Date
- 2014
- Description
- HIV mutates rapidly and may develop resistance to specific drug therapies. There is no general agreement on how to optimally schedule the available treatments for mitigating the effects of mutations. With a switched positive linear system, we examined different control strategies applied to a higher order nonlinear mutation model. Simulation results suggest that model predictive control could outperform the common clinical treatment recommendations. This brief is a step forward to develop further tools for helping the practitioners to find the optimal treatment schedule.
- Subject
- HIV; model predictive control (MPC); mutation; positive systems
- Identifier
- http://hdl.handle.net/1959.13/1295777
- Identifier
- uon:19118
- Identifier
- ISSN:1063-6536
- Language
- eng
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